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Humoral and cellular immune responses to Yersinia pestis Pla antigen in humans immunized with live plague vaccine

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Humoral and cellular immune responses to Yersinia pestis Pla antigen in humans immunized with live plague vaccine
Author summary Yersinia pestis, the causative agent of plague, has been recognized as one of the most devastating pathogen experienced by mankind. It remains endemic in many parts of the world, and is considered emerging pathogen. A live attenuated Y. pestis strain EV line NIIEG has been used for decades in the former Soviet Union for human vaccination and has proven effective against all forms of plague. We began characterizing the Y. pestis-specific antibody and T cell-mediated immune responses in people immunized with live plague vaccine. The long term goal of our research is to understand the protective mechanisms underlying...
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